The agents are given by a variety of routes of administration, doses used are inconsistent, and urine collection procedures vary. Challenge testing utilizes a variety of chelating agents, including dimercaptosuccinic acid ( DMSA), dimercaptopropanesulfonate (DMPS), and ethylenediaminetetraacetic acid (EDTA). Despite recommendations by professional and government organizations against the use of provoked urine testing, the tests are still commonly used and recommended by some practitioners. There is no standard, validated challenge test. "Urine mobilization test," " challenge test," and "provoked urine test" are all terms used to describe the administration of a chelating agent to a person prior to collection of their urine to test for metals. Recommendations for provoked challenge urine testing.
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